Temozolomide (NSC 362856), DNA Alkylator
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Descrição
Temozolomide (NSC 362856) is an oral active DNA alkylating agent that crosses the blood-brain barrier. Temozolomide is also a proautophagic and proapoptotic agent. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system. Temozolomide has antitumor and antiangiogenic effects. - Mechanism of Action & Protocol.
Marked inactivation of O6-alkylguanine-DNA alkyltransferase activity with protracted temozolomide schedules
Biomedicines, Free Full-Text
Novel Imidazotetrazine Evades Known Resistance Mechanisms and Is Effective against Temozolomide-Resistant Brain Cancer in Cell Culture
Temozolomide resistance in glioblastoma multiforme. - Abstract - Europe PMC
Frontiers An overview of glioblastoma multiforme and temozolomide resistance: can LC-MS-based proteomics reveal the fundamental mechanism of temozolomide resistance?
Bioequivalence study of 20-mg and 100-mg temozolomide capsules (TOZ309 and Temodal®) in glioma patients in China
PDF) Temozolomide and Other Alkylating Agents in Glioblastoma Therapy
Temozolomide CAS 85622-93-1 Manufacturers, Suppliers, Factory - Home Sunshine Pharma
Variant allele frequency enrichment analysis in vitro reveals sonic hedgehog pathway to impede sustained temozolomide response in GBM
Molecules, Free Full-Text
Selleck Chemical LLC Temozolomide 25mg 85622-93-1 CCRG81045, NSC 362856,TMZ
A) Sites of alkylation on the various bases in the DNA. Temozolomide
Tunable Stability of Imidazotetrazines Leads to a Potent Compound for Glioblastoma
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